Abstract Submitted to the    NANOTUBE'06 Conference:

Carbon Nanotube Biosensor for the Assessment of Personal Quality of Life

Katsuyuki Murata ¹, Masuhiro Abe ², Yasuo Ifuku ³, Atsuhiko Kojima ⁴, Mitsuaki Shimuzu ⁵, Masatoshi Maeda ⁶, Tatsuaki Ataka ¹, Kazuhiko Matsumoto ⁷

¹ Olympus Corpration
² NEDO
³ Mitsubishi Kagaku Iatron
⁴ Mitsubishi Chemical
⁵ AIST
⁶ Tsukuba University
⁷ Osaku University, CREST-JST, and AIST

k-murata@aist.go.jp

XIX. Nanotube-Based Transistors

The aim of this study is to provide home medical care facilities in distant places; this system could assist in assessing the quality of life. This system that provides medical care facilities in distant places is termed “Personal QOL.” Protein sensing is the key technology required for the construction of the Personal QOL system. A carbon nanotube field-effect transistor (CNT-FET) has potential for use as the above mentioned biosensor.
There are several problems associated with the use of a CNT-FET biosensor as an industrial product, namely, reliability, yield, and sensitivity.
The CNT-FET biosensor that was designed and made by us had a top-gate structure that improved its sensitivity and reliability. Moreover, the top-gate structure can function as a nondisposable biosensor.
This CNT-FET biosensor was tested for real-time sensing of pig serum albumin (PSA). PSA was detected on the basis of an antigen-antibody reaction. For PSA sensing, anti-PSA (a-PSA) was immobilized on the top-gate of the CNT-FET by physical adsorption. PSA was dissolved in buffer (pH = 8.0) and then reacted with the immobilized a-PSA. Our CNT-FET biosensor sensed PSA by a change in the drain current. These results will be reported in our presentation.

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