Abstract Submitted to the    NANOTUBE'06 Conference:

Nanobiotechnological Applications of Functionalised Carbon Nanotubes

Alberto Bianco

UPR9021 ICT, CNRS

A.Bianco@ibmc.u-strasbg.fr

VII. Chemical Modification of Nanotubes

Carbon nanotubes (CNT) are attracting the attention of several scientists, due to their unique structural, mechanical, electronic, chemical and biological properties [1]. These nanoobjects hold a lot of promises on biomedical applications for different reasons: high stability, water solubility, lack of intrinsic immunogenicity, efficient payload capacity, and cellular uptake [2]. The organic functionalisation has facilitated the manipulation of this nanomaterial and it has also opened the way to the potential use of CNT as novel vectors for cell internalisation of therapeutic molecules. Therefore, functionalised CNT can be considered as a promising alternative to the common drug delivery systems.

In this context, we have recently developed a novel non-viral delivery system based on cationic CNT for transfer of nucleic acids [3]. In addition, we have explored the possibility of targeted delivery of small organic molecules (antibiotics) and peptide-based synthetic vaccines [4, 5]. In this presentation we will describe the functionalisation and biological properties of nanotubes loaded with different active cargos. These conjugates are able to penetrate into the cells with reduced toxicity [6]. Their potential use for the delivery of plasmid DNA, drugs or peptides will be summarised. We will also address the critical issue of toxic effects [7].

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{\small
[1] Tasis, D.; Tagmatarchis, N.; Bianco, A.; Prato M. Chem. Rev. 2006, 106, 1105.

[2] Bianco, A.; Kostarelos, K.; Partidos, C. D.; Prato, M. Chem. Commun. 2005, 571.

[3] Pantarotto, D.; Singh, R.; McCarthy, D.; Erhardt, M.; Briand, J.P.; Prato, M.; Kostarelos, K.; Bianco, A. Angew. Chem. Int. Ed. 2004, 43, 5242.

[4] Wu, W.; Wieckowski, S.; Pastorin, G.; Benincasa, M.; Klumpp, C.; Briand, J.-P.; Gennaro, R.; Prato, M.; Bianco, A. Angew. Chem. Int. Ed. 2005, 44, 6358.

[5] Pantarotto, D.; Partidos, C. D.; Hoebeke, J.; Brown, F.; Kramer, E.; Briand, J.-P.; Muller, S.; Prato, M.; Bianco, A. Chem. Biol. 2003, 10, 961.

[6] Pantarotto, D.; Briand, J.-P.; Prato, M.; Bianco, A. Chem. Commun. 2004, 16.

[7] Singh, R.; Pantarotto, D.; Lacerda, L.; Pastorin G.; Klumpp, C.; Prato, M.; Bianco, A.; Kostarelos, K. Proc. Natl. Acad. Sci. USA 2006, 103, 3357.
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